PySimpleGui

CONSEGUI!!!

import time
import webbrowser
import PySimpleGUI as sg
import webbrowser
import pyautogui
import _thread
import sys


# pyinstaller --onefile C:\Users\01518891\PycharmProjects\core_box_image\chrome.py --noconsole


# Janela inicial, Interface do Programa
def tela_inicial():
    # Tema
    sg.theme('Reddit')

    # Conjunto de blocos do layout
    layout = [
        # Cria os espaços para colocar os links
        [sg.Text("LINK 01"),
         sg.Input(key='link_01')],

        [sg.Text("LINK 02"),
         sg.Input(key='link_02')],

        [sg.Text("LINK 03"),
         sg.Input(key='link_03')],

        [sg.Text("LINK 04"),
         sg.Input(key='link_04')],

        [sg.Text("LINK 05"),
         sg.Input(key='link_05')],

        # Controles do aplicativo
        # Botão INICIAR
        [sg.Button("INICIAR"),

         # Spin para colocar a quantidade de tempo para execução
         sg.T('TEMPO DE EXECUÇÃO (Minutos)'),
         sg.Spin((1, 2, 3, 4, 5, 6, 7, 8, 9, 10), initial_value=1, key='intervalo'),

         sg.Button("PARAR", button_color="Red")
         ]
    ]

    return sg.Window('EXIBIR LINKS EXPLORAÇÃO', layout=layout, finalize=True)


# Criar Janela
tela_inicial = tela_inicial()


def executar_chrome(link):
    if len(link) <= 0:
        pass
    else:
        webbrowser.open_new_tab(link)


def alternar_abas_chrome():
    global stop
    while True and not stop:
        pyautogui.hotkey('ctrl', 'tab')
        time.sleep(60 * int(window['intervalo'].get()))


# Gambiarra para parar o loop
stop = False


# Criando a leitura de eventos
while True:
    window, event, values = sg.read_all_windows()

    # Quando a janela for fechada
    if window == tela_inicial and event == sg.WIN_CLOSED:
        stop = True
        break

    if window == tela_inicial and event == 'INICIAR':
        stop = False

        link_01 = str(window['link_01'].get())
        link_02 = str(window['link_02'].get())
        link_03 = str(window['link_03'].get())
        link_04 = str(window['link_04'].get())
        link_05 = str(window['link_05'].get())

        executar_chrome(link_01)
        executar_chrome(link_02)
        executar_chrome(link_03)
        executar_chrome(link_04)
        executar_chrome(link_05)

        _thread.start_new_thread(alternar_abas_chrome, ())

    if window == tela_inicial and event == 'PARAR':
        stop = True

window.close()

Faltou colocar a Thread!!