Jogo final, com algumas implementações a mais.

Implementei um loop para que o usuário não selecione uma opção invalida de dificuldade.

import random

print("*******************************")
print("Wellcome to the guessing game!")
print("*******************************")

secret_number = random.randrange(1, 101)
roll = 1
attempts = 0
score = 1000
correct = 0

choice = 1
while choice:
    print("Difficult:\n")
    difficult = int(input("1 - Easy\n2 - Medium\n3 - Hard\n"))

    if difficult == 1:
        attempts = 10
        choice = 0
    elif difficult == 2:
        attempts = 5
        choice = 0
    elif difficult == 3:
        attempts = 3
        choice = 0
    else:
        print("Chose a valid difficult.\n")

for roll in range(1, attempts + 1):
    print("Attempt {} of {}".format(roll, attempts), end="\n\n")

    guess_str = input("Type a number between 1 and 100: ")
    print("Your guess is", guess_str, end="\n\n")
    guess_int = int(guess_str)

    if (guess_int < 1) or (guess_int > 100):
        print("You must enter a number between 1 and 100!")
        continue

    equals  = guess_int == secret_number
    greater = guess_int > secret_number
    smaller = guess_int < secret_number

    if equals:
        print(f"Congratulations!! The secret number is {secret_number}.\nYour score was {score}")
        correct = 1
        break
    else:
        if smaller:
            print("Secret number > ", guess_int, end="\n\n")
        elif greater:
            print(guess_int, " > Secret number.", end="\n\n")

        score_loss = abs(secret_number - guess_int)
        score -= score_loss


if correct:
    print("END")
else:
    print("You don't have more tries.")
    print(f"The secret number was {secret_number}. Good luck next time!")